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Lnhc · Berdazimer Sodium

Zelsuvmi: patented from NIH-funded research, then Medicare paid $49K for it in 2025

University of North Carolina Chapel Hill reported 2 patents on it to NIH as inventions made with NIH grant money.
Patent reported as grant-funded
Reported

$49K

Medicare paid, 2025

before rebates

Calculated

$49K

Medicare, 2020–2025

$3K per patient in 2025

Reported

$43K

Medicare, 2026 Q1

the newest quarter CMS has published

Reported

$3.1M

NIH grants behind the patents

whole-grant totals, not the drug's cost

The public record, link by link

  1. 1 · Public research

    NIH grant to University of North Carolina Chapel Hill, $3.1M in all.
  2. 2 · Patent

    8282967, 8956658, reported to NIH under R01EB000708.
  3. 3 · FDA approval

    Approved Jan 5, 2024, sold by Lnhc (NDA 217424).
  4. 4 · Public pays

    Medicare paid $49K in 2025 for 18 patients.

What Medicare paid for Zelsuvmi

Medicare Part D and Part B gross spending by year, before manufacturer rebates.
2020: $020202021: $020212022: $020222023: $020232024: $020242025: $49K2025: $49K2025

Plus $43K in the first quarter of 2026, for 17 patients.

The grants

Totals are everything NIH paid on each grant since 1985. A grant usually funded more than this one invention.
  • Nitric Oxide-Releasing Glucose Biosensors

    R01EB000708 · University of North Carolina Chapel Hill · NIBIB · 2002–2011

    $3.1M

The patents

Patents the FDA lists for this drug that were also reported to NIH as grant-funded inventions.
  • US 8282967

    Nitric Oxide-Releasing Particles for Nitric Oxide Therapeutics and Biomedical Applications

    Reported by University of North Carolina Chapel Hill

    FDA-listed expiry May 30, 2026
  • US 8956658

    Nitric Oxide-Releasing Particles for Nitric Oxide Therapeutics and Biomedical Applications

    Reported by University of North Carolina Chapel Hill

    FDA-listed expiry May 30, 2026

Lnhc's side

Drug makers pay for the clinical trials that take a compound from the lab to FDA approval, and they pay royalties on licensed patents. Those terms are not public. Lnhc's page shows its other products on this list, its federal awards, its PAC's giving and its lobbying. If Lnhc wants to add its account, we will publish it here.

How this is built. A product is listed for one of two public records. Either NIH's Technology Transfer office lists it as an FDA-approved product built on a license from an NIH, CDC or FDA lab, or a patent the FDA lists for the drug was reported to NIH as an invention made with NIH grant money, as the Bayh-Dole Act requires. We then add what Medicare Part D, Part B and Medicaid paid for each product, and for each company, the federal grants and contracts it received, its PAC's donations and its lobbying.

What the numbers mean. Medicare and Medicaid figures are gross spending before the rebates drug makers pay back, which are confidential. Hospital-administered therapies such as CAR-T cell treatments are mostly paid under Medicare Part A and do not appear in these files. "NIH grants" is everything NIH paid on the grants a patent was reported under, from 1985 on; a grant usually paid for more than one invention, so it is not the cost of the drug. Federal contracts include purchases, such as vaccine doses, as well as research. Companies also paid for the clinical trials that took these products to approval. None of these figures shows that public money set a price or bought a decision.

Sources: NIH Technology Transfer: FDA-approved products licensed from NIH, CDC and FDA labs; NIH RePORTER patents reported under NIH grants (from iEdison); NIH RePORTER project funding; FDA Orange Book patent, exclusivity and product files; CMS Medicare Part D and Part B Spending by Drug (annual and quarterly); CMS Medicaid Spending by Drug; USAspending.gov federal grants and contracts. Updated 2026-11-06.