Pedmark: patented from NIH-funded research

Oregon Health & Science University reported a patent on it to NIH as an invention made with NIH grant money.

Patent reported as grant-fundedOrphan drug

Reported

–

Medicare paid, 2025

before rebates

Calculated

–

Medicare, 2020–2025

Reported

–

Medicare, 2026 Q1

the newest quarter CMS has published

Reported

$14M

NIH grants behind the patents

whole-grant totals, not the drug's cost

The public record, link by link

1 · Public research
3 NIH grants to Oregon Health & Science University, $14M in all.
2 · Patent
10596190, reported to NIH under R01CA137488, R01NS044687, R37NS044687.
3 · FDA approval
Approved Sep 20, 2022, sold by Fennec Pharmaceuticals (NDA 212937); orphan-drug exclusivity runs to Sep 20, 2029.
4 · Public pays
Not in the Medicare Part D or Part B files, or Medicaid's. It may be off the market, generic now, or paid for inside hospital stays.

The grants

Totals are everything NIH paid on each grant since 1985. A grant usually funded more than this one invention.

Two Compartment Models to Improve Brain Tumor Therapy
R01CA137488 · Oregon Health & Science University · NCI · 2008–2019
$7.3M
Opening of the Blood Brain Barrier to Antitumor Agents
R37NS044687 · Oregon Health & Science University · NINDS · 2002–2008
$3.5M
Opening of the blood-brain barrier to antitumor agents
R01NS044687 · Oregon Health & Science University · NINDS · 2010–2014
$3.1M

The patents

Patents the FDA lists for this drug that were also reported to NIH as grant-funded inventions.

US 10596190
Method for reducing ototoxicity in pediatric patients receiving platinum-based chemotherapy
Reported by Oregon Health & Science University
FDA-listed expiry Jan 5, 2038

Fennec Pharmaceuticals's side

Drug makers pay for the clinical trials that take a compound from the lab to FDA approval, and they pay royalties on licensed patents. Those terms are not public. Fennec Pharmaceuticals's page shows its other products on this list, its federal awards, its PAC's giving and its lobbying. If Fennec Pharmaceuticals wants to add its account, we will publish it here.

How this is built. A product is listed for one of two public records. Either NIH's Technology Transfer office lists it as an FDA-approved product built on a license from an NIH, CDC or FDA lab, or a patent the FDA lists for the drug was reported to NIH as an invention made with NIH grant money, as the Bayh-Dole Act requires. We then add what Medicare Part D, Part B and Medicaid paid for each product, and for each company, the federal grants and contracts it received, its PAC's donations and its lobbying.

What the numbers mean. Medicare and Medicaid figures are gross spending before the rebates drug makers pay back, which are confidential. Hospital-administered therapies such as CAR-T cell treatments are mostly paid under Medicare Part A and do not appear in these files. "NIH grants" is everything NIH paid on the grants a patent was reported under, from 1985 on; a grant usually paid for more than one invention, so it is not the cost of the drug. Federal contracts include purchases, such as vaccine doses, as well as research. Companies also paid for the clinical trials that took these products to approval. None of these figures shows that public money set a price or bought a decision.

Sources: NIH Technology Transfer: FDA-approved products licensed from NIH, CDC and FDA labs; NIH RePORTER patents reported under NIH grants (from iEdison); NIH RePORTER project funding; FDA Orange Book patent, exclusivity and product files; CMS Medicare Part D and Part B Spending by Drug (annual and quarterly); CMS Medicaid Spending by Drug; USAspending.gov federal grants and contracts. Updated 2026-11-06.